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Endothelial cells play a central role in maintaining vascular homeostasis, regulating permeability, and mediating inflammatory responses. Among the various endothelial cell models available, Cynomolgus Monkey HUVEC cells stand out as a valuable system for researchers seeking a closer approximation t...

In the rapidly evolving landscape of cancer immunotherapy, oncolytic virotherapy has emerged as a dynamic force capable of amplifying the immune response against tumors. Once seen merely as a means of direct tumor lysis, oncolytic viruses (OVs) are now recognized for their ability to reshape the tum...

The rise of targeted protein degradation (TPD) has opened a new chapter in modern drug discovery. Unlike traditional inhibitors that merely block protein activity, degraders work by eliminating disease-causing proteins altogether through the ubiquitin–proteasome system. Behind this elegant mechanism...

When the first mRNA vaccines made global headlines, they didn't just signal a medical milestone—they sparked a revolution. Scientists suddenly realized that mRNA wasn't only a fleeting molecule of genetic code but a programmable platform capable of driving the future of gene therapy. Yet, unlocking ...

In the rapidly evolving field of gene therapy, high-quality plasmids play a crucial role as the backbone of genetic constructs. Efficient production of these plasmids is essential for preclinical research, clinical trials, and large-scale therapeutic applications. This is where contract development ...

In recent years, artificial intelligence (AI) has emerged as a transformative force in drug discovery, particularly in the design and optimization of therapeutic antibodies. Traditional antibody development relies heavily on experimental methods such as animal immunization, hybridoma screening, and ...

The realm of biopharmaceuticals plays a crucial role in modern medical treatment, yet faces significant challenges. A notable concern is the brief half-life of many biopharmaceutical products, leading to swift degradation and clearance from the patient's body, necessitating frequent dosing. This art...

The promise of cancer immunotherapy rests on a detailed understanding of how tumors and immune cells interact. Tumor tissues are highly heterogeneous, containing diverse populations of malignant, stromal, and immune cells. These cellular communities shape disease progression and influence how patien...

In the evolving landscape of cancer research, next-generation sequencing technologies have become indispensable tools to decode the complex genetic and transcriptomic landscapes of tumors. Among the foundational steps enabling this progress are DNA and RNA library preparation techniques, which direc...

When people think about therapeutic antibodies, the focus often turns to binding specificity, half-life, or effector functions. Yet beneath these well-known characteristics lies a subtler but equally decisive factor: glycosylation. These intricate sugar chains attached to antibodies are not passive ...